Unmetabolized folic acid and masking of cobalamin deficiency

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Cobalamin, folic acid, and homocysteine.

Cobalamin deficiency can lead to several adverse health consequences: folate trapping in the methylation cycle and subsequent impaired DNA biosynthesis; pernicious anemia hematologically, similar to that caused by folate deficiency; elevated blood homocysteine (tHcy) (risk factor for cardiovascular disease and adverse pregnancy outcomes); and neural tube defects (NTDs). Population-wide folate s...

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The advent of food fortification vwth folic acid along with the growing enthusiasm for vitamin supplements have made it quite possible, if not probable, that large populations in several countries are at risk for high intakes of synthetic folic acid. The ramifications of this are unknown, but there is a growing body of evidence which suggests that there may be the risk of serious health problem...

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In a randomized trial of folic acid supplementation for the prevention of colorectal adenomas, we previously found indications of increased risk during later treatment and follow-up. This could have been due to the unmetabolized folic acid (UFA) or natural reduced and methylated folates (mF) to which it is metabolized. In post hoc analyses, we measured mF (the sum of 5-methyl-tetrahydrofolate a...

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[Folic-acid deficiency].

MACROCYTIC anamia, associated with a megaloblastic erythropoiesis, glossitis, weight loss, diarrhcra, and an absence of neurological symptoms or signs and of evidence of deficiency of vitamin B12 are usually accepted as the features of deficiency of folic acid or related pteroylglutamate compounds. Such an assumption is based on the clinical and hxematological remission induced by the administr...

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Folic Acid Deficiency

MACROCYTIC anamia, associated with a megaloblastic erythropoiesis, glossitis, weight loss, diarrhcra, and an absence of neurological symptoms or signs and of evidence of deficiency of vitamin B12 are usually accepted as the features of deficiency of folic acid or related pteroylglutamate compounds. Such an assumption is based on the clinical and hxematological remission induced by the administr...

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ژورنال

عنوان ژورنال: The American Journal of Clinical Nutrition

سال: 1997

ISSN: 0002-9165,1938-3207

DOI: 10.1093/ajcn/66.6.1480